| Advanced Cell Culture Models for Substance Testing |
| P.01 |
Multicellular spheroids for toxicological evaluation of nanoparticles S. Wagner, A. Neumann, A. Lavrentieva, Leibniz Universität Hannover/D; T. Hatlapatka, C. Kasper, University of Natural Resources and Life Sciences, Vienna/ACancelled by the author |
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| P.02 |
A novel 3D model of the human air-blood barrier hosted on an ultrathin porous membrane C. Jud, University of Fribourg, Marly/CH; S. Angeloni, Centre Suisse d'Electronique et de Microtechnique, Neuchâtel/CH; M. Liley, Centre Suisse d'Electronique et de Microtechnique, Marly/CH; A. Fink, B. Rothen-Rutishauser, University of Fribourg, Marly/CH |
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| P.03 |
Differential gene expression patterns in 3D cultures of human colon cancer cells in the presence of hypoxic and/or necrotic cores S. Däster, M.G. Muraro, N. Amatruda, V. Mele, D. Calabrese, P. Zajac, G.C. Spagnoli, G. Iezzi, University Hospital of Basel/CH |
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| P.04 |
Defined multiple cell type 3D cocultures for biomaterial evaluations M. Obarzanek-Fojt, EMPA, St. Gallen/CH; N. Di Maggio, University Hospital Basel/CH; V. Zell, EMPA, St. Gallen/CH; A. Banfi, University Hospital Basel/CH; A. Bruinink, EMPA, St. Gallen/CH |
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| P.05 |
Ex vivo methodology for the efficacy testing of anti-cellulite actives I. Meyer, Symrise AG, Holzminden/D; Ma. Massironi, SCoutech, Padua/I; G. Vielhaber, Symrise SA, Clichy/F; P. Paolo, Mi. Massironi, Cutech srl, Padua/I |
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| P.06 |
The need of a simplified but reliable human placenta barrier tissue model for nanomaterial or drug testing: an organotypic microtissue approach T. Bürki-Thurnherr, Empa, St. Gallen/CH; H. Annaheim, M. Rimann, Zürcher Hochschule für Angewandte Wissenschaften, Wädenswil/CH; J.M. Kelm, Insphero AG, Zurich/CH; U. Graf-Hausner, Zürcher Hochschule für Angewandte Wissenschaften, Wädenswil/CH; P. Wick, Empa, St. Gallen/CH |
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| P.07 |
Development of a 3D tissue culture method for primary colon cancer cells B. Kvinlaug, G.C. Spagnoli, University of Basel/CH |
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| P.08 |
A primary human bronchial triple-culture model to investigate pathomechanisms of pulmonary injury M. Schäfer, C. Pohl, M. Moisch, Johannes Gutenberg University, Mainz/D; D. Steinritz, K. Kehe, Bundeswehr Institute of Pharmacology and Toxicology, Munich/D; C.J. Kirkpatrick, Johannes Gutenberg University, Mainz/D |
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| P.09 |
Development of a human in vitro 3D model to simulate the human blood brain barrier A. Appelt, H. Walles, University Clinic Würzburg/D; A. Schubert-Unkmeir, H. Slanina, University Würzburg/D |
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| P.10 |
A novel comprehensive evaluation platform to assess nanoparticle toxicity in vitro C. Hirsch, M. Roesslein, P. Wick, H.F. Krug, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen/CH |
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| P.11 |
Tissue based screening tools for testing of follicular penetration of nanoparticles A. Paulus, A. Mittal, C.-M. Lehr, S. Hansen, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbruecken/D; J. Suswind, Saarland University, Saarbrücken/D |
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| P.12 |
Absorption properties and intracellular distribution of food additives in Caco-2 cells G. Graser, P. Buchegger, U. Sauer, H. Toth-Szekely, C. Preininger, AIT - Austrian Institute of Technology, Tulln/ACancelled by the author |
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| P.13 |
Assessment of acute, long-term and chronic respiratory toxicity using a long shelf-life 3D model of the human airway epithelium (MucilAir) S. Constant, S. Huang, L. Wiszniewski, Epithelix, Plan-les-Ouates/CHCancelled by the author |
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| LMP.13.a |
New 3D-tissue/ whole-blood co-culture models combined with Multi-Analyte Profile (MAP) analyses for in-vivo-like immunopharmacology G.M. Stein, M. Blum, EDI GmbH, Reutlingen/D; J. Mapes, M. Spain, Myriad RBM, Austin/USA; T. Joos, M. Schmolz, EDI GmbH, Reutlingen/D |
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| LMP.13.b |
Human hair follicle equivalents in vitro for substance testing I. Wagner, R. Horland, G. Lindner, M. Fischer, K. Cierpka, B. Atac, S. Hoffmann, K. Schimeck, S. Brincker, M. Busek, Technical University Berlin/D; F. Sonntag, U. Klotzbach, Fraunhofer IWS Dresden/D; R. Lauster, U. Marx, Technical University Berlin/D |
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| LMP.13.c |
Downscaled 3D multi-compartment bioreactor for high-density human hepatocyte cultures as a model for hepatocyte drug metabolism. M. Lübberstedt, Charité Universitätsmedizin Berlin/D; U. Müller-Vieira, Pharmacelsus GmbH, Saarbrücken/D; S.A. Hoffmann, Charité Universitätsmedizin Berlin/D; A.K. Nüssler, University Tübingen/D; T.B. Andersson, AstraZeneca R&D, Mölndal/S; K. Zeilinger, Charité Universitätsmedizin Berlin/D |
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| LMP.13.d |
Purification of extracellular matrixes from human colon mucosa maintaining proper morphology and 3D structure L. Genovese, Scientific Institute San Raffaele, Milan/I; M. Nebuloni, L. Zawada, University of Milan/I; A. Tosoni, L. Sacco Hospital, Milan/I; M. Alfano, San Raffaele Scientific Institute, Milan/I |
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| LMP.13.e |
Example for a corrosive amine classified false-negative in an in vitro skin irritation test D. Lehmeier, H. Dr. Hofman-Hüther, BSL BIOSERVICE GmbH, Planegg/D; R. Dr. Kreiling, Clariant Produkte (Deutschland) GmbH, Sulzbach/D |
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| LMP.13.f |
The open source concept - shaping the future of animal-free tests A. Heymer, Fraunhofer Institute for Manufacturing Engineering and Automation, Stuttgart/D; L. Schober, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart/D; M. Walter, A. Traube, T. Brode, Fraunhofer Institute for Manufacturing Engineering and Automation, Stuttgart/D; T. Drescher, Fraunhofer Institute for Production Technology, Aachen/D; A. Fischer, K. Reisinger, D. Petersohn, K.R. Mewes, Henkel AG & Co. KGaA, Düsseldorf/D |
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| LMP.13.g |
Encapsulation of primary human hepatocytes into alginate beads preserves their functionality for long-term culture B. Burkhardt, J.J. Martinez Sanchez, BG Unfallklinik Tübingen/D; G. Damm, Charité Berlin/D; A.K. Nüssler, S. Ehnert, BG Unfallklinik Tübingen/D |
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| LMP.13.h |
Using HCA of cultured 3D tissues to profile and classify anti-cancer drugs D. Zi, T. Booij, B. van de Water, F. Verbeek, J. Meerman, L.S Price, Leiden University/NL |
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| LMP.13.i |
A human hepatic 3D cell model for drug discovery M.R. Lornejad-Schäfer, C. Schäfer, K.R. Schröder, BioMed-zet Life Science GmbH, Linz/A |
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| LMP.13.j |
Towards the establishment and characterisation of a human explant co-culture model with SZ95 sebocytes. G. Nikolakis, CC. Zouboulis, Dessau Medical Center/D |
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| LMP.13.k |
3D cell culture based screening platform for the identification of effective therapies for polycystic kidney disease Y. Qin, B. van de Water, Leiden University/NL; D.J.M. Peters, Leiden University Medical Center/NL; L.S. Price, Leiden University/NLCancelled by the author |
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| Advanced Cell Culture Models for Understanding of Diseases |
| P.14 |
Steering the chondrogenic phenotype
- a novel approach to improve cell based cartilage repair strategies M. Rottmar, Empa, St.Gallen/CH; M. Zenobi-Wong, V. Vogel, ETH Zurich/CH; K. Maniura-Weber, Empa, St.Gallen/CH |
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| P.15 |
Tissue engineering for drug development
- defined organotypic skin models S. Mathes, E. Bono, D. Santini, ZHAW, Wädenswil/CH; D. Schmid, Mibelle Biochemistry, Buchs/CH; U. Graf-Hausner, ZHAW, Wädenswil/CH |
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| P.16 |
Development of a human in vitro alveolar-capillary triple-culture model with an inflammatory component N. Scheele, A. Schmidt, Bundeswehr Institute of Pharmacology and Toxicology, Munich/D; C. Pohl, C.J. Kirkpatrick, Institute of Pathology, Johannes Gutenberg University Mainz/D; H. Thiermann, D. Steinritz, Bundeswehr Institute of Pharmacology and Toxicology, Munich/D |
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| P.17 |
Rho kinase inhibitor Y-27632 prolongs the life span of adult human keratinocytes, enhances skin equivalent development and facilitates lentiviral gene delivery E.H. van den Bogaard, D. Rodijk-Olthuis, P.A.M Jansen, I.M.J.J. van Vlijmen-Willems, P.E van Erp, I. Joosten, P.L.J.M Zeeuwen, J. Schalkwijk, Radboud University Nijmegen/NL |
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| P.18 |
Human artificial blood vessel tissues as a pathogenesis model in vascular biomedical research K. Rennert, K. Neunübel, University Hospital, Jena/D; S. Lorkowski, Friedrich Schiller University, Jena/D; H. Funke, S. Mosig, University Hospital, Jena/D |
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| P.19 |
Tissue engineering for drug development
- gingival wound closure models S. Mathes, T. Imhof, ZHAW, Wädenswil/CH; L. Uebersax, Geistlich Pharma AG, Wohlhusen/CH; D. Thoma, University of Zurich/CH; U. Graf-Hausner, ZHAW, Wädenswil/CH |
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| LMP.19.a |
Targeted translocation of intrabodies to different intracellular compartments to study cellular functions S. Bleick, Technical University Braunschweig and Helmholtz International Graduate School for Infection Res/D; T. Schirrmann, S. Dübel, Technical University Braunschweig/D |
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| LMP.19.b |
Investigation of cell-cell contacts and invadopodia formation of cancer cells in 3D collagen I environment J.W. Lee, M-S. Lee, T.K. Kwak, N.L. Jeon, S. Kim, Seoul National University/ROK |
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| LMP.19.c |
Molecular characterization of the tumour-stroma crosstalk using a novel 3D co-culture in vitro model A. Rudisch, Boehringer Ingelheim/ University of Vienna/A; H. van der Kuip, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart/D; H. Dolznig, Medical University of Vienna/A; P. Garin-Chesa, W. Sommergruber, Boehringer Ingelheim RCV, Vienna/A |
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| LMP.19.d |
In vitro development of an artery wall using a biodegradable scaffold to mimic a human blood vessel Y. Steffen, S. Wagner, Philip Morris, Neuchatel/CH; S. Lebrun, Philip Morris, Neuchate/CH; M. Moehring, P. Vanscheeuwijck, Philip Morris, Cologne/D; M. Peitsch, Philip Morris, Neuchate/CH |
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| LMP.19.e |
Organotypical epithelial 3D tissues (MatTek®) exposed in vitro to whole smoke as a potential alternative to rodent inhalation studies S. Wagner, Y. Steffen, C. Mathis, P. Vanscheeuwijck, Philip Morris, Neuchatel/CH |
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| LMP.19.f |
Modeling effects of tumor-stroma interaction in 3D spheroid cultures in vitro D. Dauscher, B. Mueller, German Cancer Research Center, Heidelberg/D; T. Paatsch, Hochschule Furtwangen University, Villingen-Schwenningen/D; H. Busch, University of Freiburg/D; M.M. Mueller, Hoschschue Furtwangen University and German Cancer Research Center, Villingen-Schwenningen/D |
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| Advanced Cell Culture Models for ADME - Safety Testing of Drugs |
| P.20 |
An organotypic microliver platform for high throughput drug toxicity testing S. Messner, InSphero AG, Zurich/CH; M. Uteng, Novartis, Basel/CH; N. Fried, InSphero AG, Zurich/CH; S. Hammad, Ifado, Dortmund/D; J.M. Kelm, InSphero AG, Zurich/CH; J.G. Hengstler, Ifado, Dortmund/D; A. Wolf, F. Pognan, Novartis, Basel/CH; W. Moritz, InsPhero AG, Zurich/CH |
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| P.21 |
3D-Spheroid cultivation system for liver cells for drug safety testing D. Mueller, E. Heinzle, F. Noor, Saarland University, Saarbruecken/D |
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| P.22 |
Use of three dimensional skin models for estimation of genotoxic effects in an automated assay D. Dressler, K. Engelhart-Jentzsch, BioTeSys GmbH, Esslingen/D; M. Moreno-Villanueva, University of Konstanz/D |
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| Advanced Cell Culture Models for Industrial Applications |
| P.23 |
Cryopreservation of spherical 3D tumor microtissues M. Rimann, F. Novak, ZHAW, Wädenswil/CH; N. Fried, J.M. Kelm, InSphero AG, Zürich/CH; U. Graf-Hausner, ZHAW, Wädenswil/CH |
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| P.24 |
Bioavailability and toxicity in cell cultures testing oral applications B. Schnyder, K. Eyer, University of Applied Sciences, Sion/CH |
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| LMP.24.a |
Fluorescence-based analysis of drug sensitivity in tumor microtissues M. Drewitz, InSphero AG, Zurich/CH; M. Salomon, Sirion Biotech GmbH, Munich/D; C. Oberdanner, Tecan Austria GmbH, Grödig/A; C. Thirion, Sirion Biotech GmbH, Munich/D; J.M. Kelm, InSphero AG, Zurich/CH |
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| Enabling Technologies - Devices for 3D Cell Culture |
| P.25 |
Oxygen consumption by hESC derived cardiomyocytes using micro respiration technique for viability assessment F. Noor, A. Strigun, Saarland University, Saarbrücken/D; D. Steel, P. Sartipy, Cellartis, Göteborg/S; S. Arain, C. Krause, Presens GmbH, Regensburg/D; E. Heinzle, Saarland University, Saarbrücken/D |
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| P.26 |
Microfluidic approaches and impedance spectroscopy for screening of spherical microtissues O. Frey, Z. Schumacher, A. Hierlemann, ETH Zurich, Basel/CH |
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| P.27 |
Online monitoring of 3D hepatic microtissue using electrochemical microsensors J. Wiest, cellasys GmbH, Munich/D; S. Messner, InSphero AG, Zürich/CH; B. Wolf, Technical University Munich/D |
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| P.28 |
Cell seeding strategies for MSC cultivation on three dimensional scaffolds A. Neumann, S. Kress, S. Wagner, Leibniz University Hannover/D; T. Hatlapatka, University of Natural Resources and Life Sciences, Vienna/A; B. Weyand, Hannover Medical School/D; C. Kasper, University of Natural Resources and Life Sciences, Vienna/ACancelled by the author |
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| P.29 |
Validation of a bioreactor with quiescent HepaRG cells R. Hoekstra, G.A.A. Nibourg, T.V. Van der Hoeven, University of Amsterdam/NL; C. Chesné, Biopredic International, Rennes/F; M.T. Ackermans, R.P.J. Oude Elferink, T.M. Van Gulik, R.A.F.M. Chamuleau, University of Amsterdam/NL |
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| P.30 |
Proliferation of human primary T lymphocytes inside of polyelectrolyte capsules M. Werner, V. Jérôme, University of Bayreuth/D; K. Zambrano, H. Hübner, R. Buchholz, University of Erlangen-Nürnberg/D; R. Freitag, University of Bayreuth/D |
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| P.31 |
Cytological assessment of hepg2 cell culture grown under two and three dimensional conditions U. Fernekorn, J. Hampl, F. Weise, M. Klett, A. Läffert, A. Schober, Ilmenau University of Technology/D |
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| P.32 |
Production and comparison of thermoformed polylactide 3D scaffolds with polycarbonate made 3D structures for the application in advanced cell culture M. Gebinoga, Ilmenau University of Technology/D; J. Tobola, Wrozlaw University of Technology/PL; J. Hampl, Ilmenau University of Technology/D; T. Elsarnagawy, Y.A. Elnakady, H. Fouad, F. Almajhadi, King Saud University, Riyadh/SAR; U. Fernekorn, F. Weise, M. Klett, A. Läffert, Ilmenau University of Technology/D; D. Elsarnagawy, Academy for Scientific Research and Technology, Cairo/ET; A. Schober, Ilmenau University of Technology/D |
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| LMP.32.a |
Engineered perfusable microvascular networks and angiogenic sprouts on a microfluidic chip N.L. Jeon, J.W. Lee, S.H. Kim, Medicinal Bioconvergence Research Center, Seoul/ROK |
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| LMP.32.b |
Perfused 3D human liver equivalents for biomedical research E. Materne, T. Hasenberg, R. Horland, Technical University Berlin/D; H. Walles, Stuttgart University/D; R. Lauster, U. Marx, Technical University Berlin/D |
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| LMP.32.c |
Building endothelial cell covered microfluidic 3D channels in miniaturized bioreactors K. Schimek, R. Horland, S. Brincker, U. Menzel, I. Wagner, E.-M. Materne, S. Hoffmann, M. Busek, TU Berlin/D; F. Sonntag, U. Klotzbach, Fraunhofer IWS Dresden/D; R. Lauster, U. Marx, TU Berlin/D |
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| LMP.32.d |
Raman spectroscopy - a new method for label-free and non-invasive monitoring of cells and tissue K. Schütze, S. Koch, CellTool GmbH, Tutzing/D |
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| LMP.32.e |
Microfluidic in-vitro models for the investigations of the pathophysiology of pulmonary diseases M. Felder, C. Vogt, E. Marconi, University of Bern/CH; A. Gazdhar, Th. Geiser, University Hospital of Bern/CH; O. Guenat, University of Bern/CH |
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| LMP.32.f |
NovaMatrix-3D - 3D cell culture and formation of multi-cellular structures in alginate foams T. Andersen, C. Markussen, M. Dornish, FMC BioPolymer, Sandvika/N |
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| LMP.32.g |
Online biosensor for 3D organoid culture metabolism monitoring S.A. Khaustova, E.V. Trushkin, D.A. Sakharov, SRC Bioclinicum LTD, Moscow/RUS; U. Marx, Technische Universitaet Berlin/D; E.A. Andreev, O.G. Voronin, A.A. Karyakin, Moscow State University/RUS; A.G. Tonevitsky, The Institute of General Pathology and Pathophysiology RAMS/RUS |
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| LMP.32.h |
Survival of cord blood hematopoietic stem cells in a hyaluronan hydrogel for ex vivo biomimicry E. Demange, Y. Kassim, C. Petit, C. Buquet, V. Dulong, D. Le cerf, JP. Vannier, Université de Rouen/F |
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| LMP.32.i |
Cell-seeded thermoreversible hydrogel-polyurethane composites for nucleus pulposus augmentation B. Striegl, Zurich University of Applied Sciences/AO Research Institute, Waedenswil/Davos/CH; S. Grad, D. Eglin, AO Research Institute, Davos/CH; L. Benneker, Insel Hospital, Bern/CH; M. Peroglio, M. Alini, AO Research Institute, Davos/CH; U. Graf-Hausner, E. Bono, Zurich University of Applied Sciences, Waedenswil/CH |
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| LMP.32.j |
Tools for long time 3D cell culture M. Giazzon, M. Favre, S. Ahmed, S. Angeloni, M. Liley, CSEM.SA, Neuchatel/CH |
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| LMP.32.k |
New platform technology for simple, consistent production of collagen-based 3D cell cultures for physiologically relevant assays C.M. Villemant, A. Kaasi, A.B. Lintott, TAP Biosystems, Royston/UK; R.A. Brown, UCL, London/UK; R.A.L. Drake, TAP Biosystems, Royston/UK |
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| LMP.32.l |
Flow-through bioreactors as a tool for continuous 3D-culture C. Goepfert, G. Blume, R. Faschian, S. Meyer, A. Dittmann, W. Saß, J. Müller, Technical University Hamburg-Harburg/D; J. Fischer, F. Feyerabend, Helmholtz-Zentrum Geesthacht/D; R. Pörtner, Technical University Hamburg-Harburg/D |
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| LMP.32.m |
The influence of ionizing radiation (IR) on adhesion molecules associated with invasion and metastasis of malignant melanoma (MM) cells B. Biswas, University of Zurich/CH and Dessau Medical Centre/D; A.M. Hossini, H. Seltmann, C.C. Zouboulis, Dessau Medical Centre/D; I.F. Ciernik, University of Zurich/CH and Dessau Medical Centre/D |
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| Enabling Technologies - Systems Biology |
| P.33 |
Establishment of human tumor models on a novel 3D collagen matrix with distinct morphology depending on degree of malignancy and cancer type as basis for computational prediction of treatment strategies S. Nietzer, C. Moll, A. Stratmann, G. Wangorsch, G. Dandekar, H. Walles, University of Wuerzburg/D |
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| P.34 |
Functionalization and 3D culture of fetal osteoblasts for the development of bone implant F. Borcard, D. Staedler, A. Godinat, H. Comas, EPF, Lausanne/CH; F. Krauss-Juillerat, ETH, Zürich/CH; S. Gerber-Lemaire, EPF, Lausanne/CH; U.T. Gonzenbach, ETH, Zürich/CH; L. Juillerat-Jeanneret, CHUV, Lausanne/CHCancelled by the author |
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| LMP.34.a |
Organotypic cultures of bronchial epithelial cells exposed to cigarette smoke mimic molecular perturbations seen in smoker's lung epithelium C. Mathis, C. Poussin, Philip Morris International, Neuchâtel/CH; D. Weisensee, S. Gebel, Philip Morris Research Laboratories GmbH, Cologne/D; V. Belcastro, Y. Xiang, A. Sewer, Philip Morris International, Neuchâtel/CH; A. Hengstermann, Philip Morris Research Laboratories GmbH, Cologne/D; S. Ansari, S. Wagner, J. Hoeng, M. Peitsch, Philip Morris International, Neuchâtel/CH |
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| LMP.34.b |
Cell matrix interactions in 3D alginate cell culture system T. Andersen, FMC BioPolymer, Sandivka/N; C. Markussen, M. Dornish, FMC BioPolymer, Sandvika/N |
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| Enabling Technologies - Stem Cells |
| P.35 |
Towards automation of the embryonic stem cell test S. Ströbel, J. Lichtenberg, W. Moritz, J.M. Kelm, InSphero AG, Zurich/CH |
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| P.36 |
Proliferation rate as an indicator for the chondrogenic potential of mesenchymal stromal cells in 3D pellet culture D. Studer, Empa / ETH Zurich, St.Gallen/CH; M. Zenobi-Wong, ETH, Zurich/CH; K. Maniura-Weber, Empa, St.Gallen/CH |
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| P.37 |
A powerful 3D culture strategy for integrating expansion and cryopreservation of human embryonic stem cells M. Serra, C. Correia, R. Malpique, C. Brito, ITQB-UNL/IBET, Oeiras/P; J. Jensen, Cellartis AB, Gothenburg/S; P. Bjorquist, Cellartis AB, Gothemburg/S; M. Carrondo, FCT-UNL, Monte da Caparica/P; P. Alves, ITQB-UNL/IBET, Oeiras/P |
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| LMP.37.a |
Cell viability and adipogenic differentiation assessment in collagen-sericin-based 3D culture systems S. Dinescu, B. Galateanu, O. Calciu, University of Bucharest/RO; M. Albu, Leather and Footwear Research Institute, Bucharest/RO; A. Cimpean, M. Costache, University of Bucharest/RO |
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| LMP.37.b |
New porous interpenetrating polymeric network designed for adipose derived stem cells 3D culture B. Galateanu, University of Bucharest/RO; S. Dinescu, University of Bucharest/RO; I. Stancu, A. Lungu, University Politehnica Bucharest/RO; O. Calciu, A. Cimpean, M. Costache, University of Bucharest/RO |
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| LMP.37.c |
Scaffolds designed for mesenchymal stem cells based on nonwoven technology R. Ross, A. Arshi, T. Gries, S. Jockenhoevel, A. Schellenberg, W. Wagner, RWTH University, Aachen/D |
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