Lecture Programme
Thursday, 5 March 2009
10:30 Welcome address
Large-scale and functional protein analysis
10:40
Probe the sample twice - mag bead arrays in line
O. Pötz
, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen; T. Henzler, Merck KGaA, Darmstadt; C. Kazmaier, NMI Natural and Medical Sciences
Institute at the University of Tübingen, Reutlingen; T. Herget, Merck KGaA, Darmstadt; T.O. Joos, NMI Natural and Medical Sciences Institute at the University of Tübingen,
Reutlingen
11:00
HaloLink
TM
protein arrays for functional protein analysis
T. Bui,
Promega GmbH, Mannheim; N. Nath, R. Hurst, B. Hook, K. Zhao, D. Klaubert, D. Storts, B. Bulleit, P. Bresnahan, Promega Corporation, Madison, WI/USA
11:20
Platform to assess undesirable direct interactions of polyclonal affinity purified secondary antibodies with peptides on high density peptide microarrays
P. Lorenz, University of Rostock; Z. Qian, SIBS, Shanghai/PRC; M. Hecker, IndyMed, Rostock; L. Hong, Y. Li, SIBS, Shanghai/PRC; M. Glocker,
H.-J. Thiesen
, University of Rostock
11:40 Coffee break and poster viewing
Medical applications of chip technologies
12:00
Protein chips-"multi-parameter-analysis"- from development to clinical applications
H. Paul
, U. Klause, H. Hornauer, H.-J. Müller, B. Risse, Roche Diagnostics GmbH, Penzberg
12:20
From arrays towards fighting the tuberculosis epidemic
G. Michel, FIND - Foundation for Innovative New Diagnostics, Geneva/CH
12:40
Characterization of the autoimmune antibody repertoire of Parkinson's disease patients by systematic screening of protein arrays
H. Goehler
, A. Kowald, Ruhr-University Bochum; A. Lueking, Protagen AG, Dortmund; M. Gerlach, University of Würzburg; H. Meyer, Ruhr-University Bochum
13:00 Lunch break
Cell-based assays
14:30
Monitoring cell differentiation on multiple substrate arrays
C. Maercker
, F. Graf, M. Angstmann, Mannheim University of Applied Sciences; D. Breitkreutz, DKFZ, Heidelberg
14:50
Functional screening of CNS drug candidates with neuronal networks on microelectrode arrays
O.H.-U. Schroeder
, NeuroProof GmbH, Rostock; A. Gramowski, University of Rostock; K. Jügelt, NeuroProof GmbH, Rostock; D.G. Weiss, University of Rostock
15:10
Roaming capability: a new area based measure of „productive“ cell migration in high throughput analyses
J. Huth
, M. Buchholz, T.M. Gress, University of Marburg; H.A. Kestler, University of Ulm
15:30 Coffee break and poster viewing
Novel platform concepts I
16:00
Self-assembly of protein-microarrays in microfluidc systems
H. Schröder
, C.M. Niemeyer, TU Dortmund
16:20
L-DNA universal microarray platform for the analysis of breast cancer
R. Martinez
, A. Jacob, DKFZ, Heidelberg; N. Hauser, Fraunhofer IGB, Stuttgart; R. Helwa, J. Hoheisel, DKFZ, Heidelberg
16:40
Repeatable printing of protein microarrays from DNA microarrays
O. Stoevesandt
, Babraham Bioscience Technologies, Cambridge/UK; M. He, Babraham Institute, Cambridge/UK; M.J. Taussig, Babraham Bioscience Technologies,
Cambridge/UK
17:00 Coffee break and poster viewing
17:30
1
st
plenary lecture
The small RNA zoo
E. Miska, Cancer Research Gurdon Institute, Cambridge/UK
18:15
Poster party, selection of the best posters
20:15 End of the first day
Friday, 6 March 2009
Novel platform concepts II
9:00
A novel fluidic microarray for dynamic detection and quantification of proteins
M. Rendl
, T. Brandstetter, J. Rühe, University of Freiburg
9:20
Application of 3'- fluorophore-labeled nucleotides in chemical primer extension reactions
K. Gießler, T. Lommel, M. Röthlingshöfer, University of Karlsruhe (TH); E. Kervio,
C. Richert
, University of Stuttgart
9:40
DNAzyme as alternative detection tool for DNA microarrays
D. Köster
, D. Haselbach, H. Seitz, MPI for Molecular Genetics, Berlin
10:00
Novel applications for custom-made oligo array-CGH microarrays: high resolution analysis of chromosomal aberrations in immunogenetics and cancer
S. Kotschote
, R. Oehlmann, IMGM Laboratories GmbH, Martinsried; U. Heinrich, K. Mayer, K. Hirv, Zentrum für Humangenetik und Laboratoriumsmedizin, Dr. Klein und Dr. Rost,
Martinsried
10:20
Poster award
10:40 Coffee break and poster viewing
Novel concepts in genomic profiling
11:10
2
nd
plenary lecture
Chips, cells and single molecules
G. Schütz, Johannes-Kepler-University Linz/A
11:55
Targeted next-generation-sequencing by specific capture of multiple genomic loci using low-volume microfluidic DNA-arrays
S. Bau, N. Schracke, M. Kränzle, febit biomed gmbh, Heidelberg; H. Wu, febit Inc., Lexington, MA/USA; P.F. Stähler, febit biomed gmbh, Heidelberg; J.D. Hoheisel, DKFZ,
Heidelberg; M. Beier,
D. Summerer
, febit biomed gmbh, Heidelberg
12:15
OnSpot melting curve offers new dimension for SNP diagnostics
C. Reschreiter, Anagnostics Bioanalysis GmbH, Linz/A
12:35
3
rd
plenary lecture
Chip-based technology to discover the genetic etiology of complex diseases
S. Schreiber, University of Kiel
13:20
Closing remarks
13:30 Lunch and end of the conference
P01
Enzymatic on-chip labeling of miRNAs using microfluidic microarrays
S. Vorwerk
, K. Ganter, Y. Cheng, B. Haase, M. Beier, febit biomed gmbh, Heidelberg
P02
Laser ablation ICP-MS as a quantitative tool for microarray detection
C. Peter,
M.G. Weller, U. Panne, BAM Federal Institute for Materials Research and Testing, Berlin
P03
Adaptation of the marine model organism
Rhodopirellula baltica
SH1
T
to environmental changes
C. Klockow
, P. Wecker, A. Ellrott, F.O. Glöckner, MPI for Marine Microbiology, Bremen
P04
Optimization of aptamer immobilization for protein microarray applications
M. Lübbecke
, J.-G. Walter, F. Stahl, T. Scheper, University of Hannover
P05
Direct enzymatic incorporation of fluorophores on DNA microarrays via rolling circle amplification (RCA)
L. Linck
, E. Mayer-Enthart, J. Sialleli, K. Rurack, BAM Federal Institute for Materials Research and Testing, Berlin; D. Köster, H. Seitz, MPI for Molecular Genetics, Berlin;
U. Resch-Genger, U. Panne, BAM Federal Institute for Materials Research and Testing, Berlin
P06
Ligation based capture probe design for label-free DNA microarrays of improved specifity
F. Rühle
, R. Zelm, D. Blohm, University of Bremen
P07
Bioinformatical approaches for the identification of disease biomarkers
A. Kowald
, H.E. Meyer, Ruhr University Bochum; J. Beator, A. Lueking, Protagen AG, Dortmund
P08
Nanotopographic spot characterization of chemo-chips by AFM and long-range nano profiling
A. Thete
, N. Dorozhovets, G. Jäger, J.M. Köhler, TU Ilmenau
P09
16S rRNA-targeted DNA microarrays - a potential routine tool for the high throughput characterization of marine bacterioplankton communities?
M. Kassabgy
, A. Ellrott, J. Peplies, B.M. Fuchs, R. Amann, MPI for Marine Microbiology, Bremen
P10
Large scale quantitative analysis of tumor samples using protein microarrays
H. Mannsperger
, C. Bender, C. Schmidt, C. Löbke, DKFZ, Heidelberg; F. Haller, University of Göttingen; F. Henjes, H. Sültmann, DKFZ, Heidelberg; L. Füzesi, University of Göttingen;
S. Wiemann, T. Beissbarth, U. Korf, DKFZ, Heidelberg
P11
Comparing manual, partly and full automated microarray hybridization protocols
N. Stralis-Pavese, T. Tüchler, Boku University, Vienna/A; B. Fischer, S. Russell, University of Cambridge/UK; P. Sykacek,
D.P. Kreil
, Boku University, Vienna/A
P12
Description of genomic imbalances in adrenocortical carcinoma (ACC) using gene chip copy number analysis (CNA) from Affymetrix
N. Posorski
, University of Jena; P. Bucksky, Medizinische Universität Lübeck; I.F. Loncarevic, Clondiag GmbH, Jena
P13
Chip-based DNA detection using SERS and silver colloids within a microfluidic chamber
K. Strelau
, W. Uhlemann, R. Moeller, University of Jena; W. Fritzsche, Institute of Photonic Technology, Jena; J. Popp, University of Jena
P14
Reproducible nanostructured gold surfaces for analytical devices - characterization of the anisotropic properties of gold nanodiamond arrays and their bioanalytical
application
D. Cialla
, University of Jena; U. Hübner, Institute of Photonic Technology, Jena; J. Petschulat, University of Jena; H. Schneidewind, R. Mattheis, Institute of Photonic Technology,
Jena; T. Pertsch, R. Möller, University of Jena; J. Popp, University of Jena and Institute of Photonic Technology, Jena
P15
Gene expression profiling of chilling tolerance in maize
R. Deenen
, E. Pestsova, P. Westhoff, K. Köhrer, University of Düsseldorf
P16
The gene expression profiling facility of the BMFZ
R. Deenen
, K. Köhrer, University of Düsseldorf
P17
Surface analytical measurements (XPS, ToF-SIMS, NEXAFS) of organosilane functionalized substrates to be used as microarray platforms
N. Graf
, P. Dietrich, BAM Federal Institute for Materials Research and Testing, Berlin; W. Weigel, Scienion AG, Berlin; A. Lippitz, D. Treu, T. Wirth, W.E.S. Unger, BAM Federal
Institute for Materials Research and Testing, Berlin
P18
Surface chemical imaging (XPS and ToF-SIMS) of DNA microarrays
N. Graf, P. Dietrich, T. Gross, T. Wirth, BAM Federal Institute for Materials Research and Testing, Berlin; W. Weigel, Scienion AG, Berlin;
W.E.S. Unger
, BAM Federal Institute for
Materials Research and Testing, Berlin
P19
Generation of homogenous epoxy- and aminomodified nanoparticle-coatings for biochiptechnology applying spraying technique and inkjet printing
J. Plankalayil
, University of Stuttgart; M. Herz, Fraunhofer IGB, Stuttgart; D. Kaltenbacher, Fraunhofer IPA, Stuttgart; A. Weber, Fraunhofer IGB, Stuttgart; G.E.M. Tovar, T. Hirth,
University of Stuttgart and Fraunhofer IGB, Stuttgart; J. Stallkamp, A. Grzesiak, Fraunhofer IPA, Stuttgart; K. Borchers, Fraunhofer IGB, Stuttgart
P20
On-chip-PCR and integration with DNA-microarray technology for fast DNA-analysis
S. Julich
, M. Urban, M. Kielpinski, Institute of Photonic Technology, Jena; S. Werres, Julius-Kühn-Institute, Braunschweig; R. Möller, University of Jena; W. Fritzsche, T. Henkel,
Institute of Photonic Technology, Jena
P21
Antibody microarrays for the profiling of cancer proteomes
C. Schröder
, A. Nieters, S. Rüffer, A. Bauer, A. Jacob, K. Fellenberg, J.D. Hoheisel, DKFZ, Heidelberg
P22
Integrated genomic profiling based on a universal array platform for improved classification of aggressive b-cell lymphoma
S.U. Weishaupt
, University of Stuttgart and Fraunhofer IGB, Stuttgart; R. Martinez, J.D. Hoheisel, DKFZ, Heidelberg; S. Rupp, N.C. Hauser, Fraunhofer IGB, Stuttgart
P23
Antibody-based signal amplification improves specific target detection on reverse phase protein arrays
J.C. Brase
, H. Mannsperger, H. Fröhlich, C. Schmidt, M. Wosch, H. Sültmann, U. Korf, DKFZ, Heidelberg
P24
Peptide microarrays to analyze DNA/protein interactions
M. Dauber
, R. Martinez, M. Schnölzer, J. Hoheisel, A. Jacob, DKFZ, Heidelberg
P25
A quantitative microspot immunoassay for cancer systems biology
F. Henjes
, T. Beissbarth, C. Schmidt, D. Arlt, S. Wiemann, U. Korf, DKFZ, Heidelberg
P26
Improving performance of bacterial identification DNA arrays by ROC-analysis guided probe design
H. Peter
, T.T. Bachmann, University of Edinburgh/UK
P27
Successful tumor-marker definition using a multiplexed assay for DNA methylation testing of over 300 methylation candidate markers
A. Weinhaeusel
, M. Hofner, M. Wielscher, P. Palicka, S. Schönthaler, M. Lauss, A. Kriegner, K. Vierlinger, R. Pichler, C. Noehammer, Austrian Research Centers GmbH,
Seibersdorf/A
P28
Microarray-based investigations on binding kinetics of biomolecules
A. Bönisch
, T. Brandstetter, J. Rühe, University of Freiburg
P29
Antibody microarrays based on microstructured surface-attached hydrogels for clinical applications
A. Evers
, University Hospital Freiburg; M. Moschallski, T. Brandstetter, J. Rühe, University of Freiburg
P30
RGG: dynamic GUI generation for microarray analysis software
I. Visne,
K. Vierlinger,
E. Dilaveroglu, A. Yildiz, C. Noehammer, Austrian Research Centers GmbH, Seibersdorf/A; F. Leisch, University of Munich; A. Kriegner, Austrian Research
Centers GmbH, Seibersdorf/A
P31
Defined surface modification improves microarray technology
T. Brandstetter, University of Freiburg; A. Mader, University Medical Centre Freiburg; A. Bönisch, University of Freiburg; A. Evers, University Hospital Freiburg; M. Rendl, O. Prucker,
J. Rühe
, University of Freiburg
P32
Comparison of a polymer-based DNA biochip platform with a commercial PCR followed by reverse hybridisation for the detection and genotyping of human papilloma virus
(HPV) in clinical samples
T. Schenk, University Medical Centre Freiburg;
T. Brandstetter
, University of Freiburg; A. zur Hausen, University Medical Centre Freiburg; J. Alt-Mörbe, Laboratory for DNA-Analytics,
Freiburg; D. Huzly, University Medical Centre Freiburg; J. Rühe, University of Freiburg
P33
On-chip multiplex NASBA
A. Mader
, U. Riehle, University Medical Centre Freiburg; T. Brandstetter, J. Rühe, University of Freiburg
P34
Modulation of the
Streptococcus pneumoniae
genome by transformation events
P. Maurer
, R. Hakenbeck, TU Kaiserslautern
P35
Chip-based detection of epizootics for point-of-care-analytics
A. Brinker
, R. Möller, M. Schwarz, B. Seise, University of Jena; J. Popp, IPHT Jena
P36
Porcine hepatic expression profiles - models to study the complex nature of obesity related traits and genotype-diet-interaction
K. Wimmers
, E. Murani, S. Ponsuksili, Research Institute for the Biology of Farm Animals, Dummerstorf
P37
Cluster number evaluation for functional genomics via robustness analysis and multi-objective optimization
J.M. Kraus
, H.A. Kestler, University of Ulm
P38
Rapid sepsis diagnostics with nanoparticle-biochips
S.C. Hartmann
, M.K. Mai, University of Stuttgart and Fraunhofer IGB, Stuttgart; Y. Kumar, GATC Biotech AG, Konstanz; C.M. Kim, Pusan National University/ROK; K. Borchers,
A. Weber, Fraunhofer IGB, Stuttgart; G. Tovar, S. Rupp, University of Stuttgart and Fraunhofer IGB, Stuttgart; N. Hauser, Fraunhofer IGB, Stuttgart
P39
Identification of hexanucleotide-based lead compounds by array-based screening for oligonucleotide-protein interactions
W. Wünsche, A. Mescalchin,
G. Sczakiel
, University of Lübeck
P40
Combining single-molecule fluorescence spectroscopy with stoichiometric labeled substrates into an ultra-sensitive protease detection assay
A. Friedrich
, A. Jacob, J. Hess, J.D. Hoheisel, J.-P. Knemeyer, DKFZ, Heidelberg; N. Marme, University of Heidelberg
P41
Candida albicans
SNP typing for resistance-associated mutations via microarray
M.K. Mai
, S.C. Hartmann, University of Stuttgart and Fraunhofer IGB, Stuttgart; N.C. Hauser, S. Rupp, Fraunhofer IGB, Stuttgart
P42
Significant binarization of noisy gene expression data
M. Hopfensitz
, H.A. Kestler, University of Ulm
P43
Customized surfaces for BioChips
C. Heise
, U. Schedler, PolyAn GmbH, Berlin
P44
Labelling of lipophilic liquids by adding oligomeric peptide nucleic acids (PNA) or deoxyribonucleotides (DNA)
A. Nies
, W. Weinig, J.P. Knemeyer, A. Jacob, J.D. Hoheisel, DKFZ, Heidelberg
P45
Functional analysis of nemorosone-induced cytotoxicity on pancreatic cancer cells
F. Holtrup
, A. Bauer, K. Fellenberg, DKFZ, Heidelberg; R.A. Hilger, University of Essen; J.D. Hoheisel, DKFZ, Heidelberg
P46
Development of a tiling array to analyze adenoviral gene expression
G. Centmeyer
, F. Holtrup, D.E. Dorer, DKFZ, Heidelberg; S. Haas, MPI for Molecular Genetics, Berlin; D.M. Nettelbeck, J.D. Hoheisel, DKFZ, Heidelberg
P47
Automated production of FAST slides greatly reduces surface variability
J. Manimala, D. English, D. Pawlak, G. Merlock, Whatman Inc., Sanford, ME/USA;
M. Walther
, Whatman GmbH, Dassel; M.A. Harvey, Whatman Inc., Sanford, ME/USA
P48
Utilizing Boolean classifers for microarray experiments
L. Lausser
, M. Maucher, University of Ulm; M. Buchholz, University of Marburg; C. Müssel, H.A. Kestler, University of Ulm
P49
Microarray-based analysis of DNA methylation in pancreatic cancer
M. Schanne
, S. Kutschmann, C. Stegmüller, S. Widder, A. Börner, A. Bauer, J. Hoheisel, DKFZ, Heidelberg
P50
LaMBADA: laboratory management system for bioarrays and data analysis
C. Lanzerstorfer,
C. Mittermayr,
Lambda GmbH, Freistadt/A; K. Pröll, FH Oberösterreich, Hagenberg/A
P51
Assessment of the hybridization chain reaction for the amplification of signal on DNA microarrays
C. Del Rio, Lambda GmbH, Freistadt/A; A. Vinelli, M. Onofri, University of Bologna/I;
C. Mittermayr
, P. Winklehner, Lambda GmbH, Freistadt/A; G. Zuccheri, University of Bologna/I
P52
Setting up a transcription factor proteins array technology detecting DNA-protein interactions
R. Helwa
, R. Martinez, A. Bauer, DKFZ, Heidelberg; J. Taipale, Biomedicum Helsinki/FIN; J. Hoheisel, DKFZ, Heidelberg
P53
RhoGTPase signalling - a protein-protein-interaction array
S. Rimmele
, N. Schneiderhan-Marra, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen; P. Gierschik, University of Ulm; T.O. Joos,
NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen
P54
Array based protein expression analysis: cell signalling in ß-Catenin deficient murine liver after treatment with non-genotoxic carcinogens
Y. Heubach
, T. Knorpp, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen; A. Braeuning, M. Schwarz, University of Tübingen; M.F. Templin,
NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen
P55
A snapshot of a protein in one experiment - ß-Catenin and its functions
K. Luckert,
O. Pötz
, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen; F. Götschel, University of Freiburg; P. Sorger, Harvard Medical School,
Boston, MA/USA; A. Hecht, University of Freiburg; T.O. Joos, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen
P56
Biomarker expression profiling on a WideScreen
TM
T. Henzler
, Merck KGaA, Darmstadt; C. McMahon, S. Hayes, EMD Chemicals, Madison, WI/USA; D. Eisinger, Rules Based Medicine, Austin, TX/USA; P. Hewitt, Merck KGaA,
Darmstadt; D. Hoffmann, A. Mally, University of Würzburg; T. Herget, Merck KGaA, Darmstadt
P57
A microarray-based method to analyze pooled RNAi screens
M. Böttcher
, DKFZ, Heidelberg; D. Canaani, Tel Aviv University/IL; J.D. Hoheisel, DKFZ, Heidelberg
P58
A reliable, rapid and easy-to-use world-to-chip interface
F. Fritzsch
, H. Kortmann, ISAS - Institute for Analytical Sciences, Dortmund; L.M. Blank, A. Schmid, ISAS - Institute for Analytical Sciences, Dortmund and TU Dortmund
P59
Real-time microarray hybridization as a tool for a better understanding of biological specificity
S. Krainer
, L. Bodrossy, M. Stierschneider, S. Fluch, Austrian Research Centers GmbH, Seibersdorf/A
P60
Drugs of abuse array II for the simultaneous screening of multiple drugs of abuse in a single blood sample on the fully-automated analyser evidence
R
R. Neill, F.M. McPhillips,
C. Finnegan
, J. Darragh, R.I. McConnell, S.P. Fitzgerald, Randox Laboratories Ltd. , Co. Antrim/UK
P61
Highly sensitive determinations of a complete panel of hormones using biochips
E. Ehrentreich-Förster
, FhG IBMT, Potsdam; R. Greb, Kinderwunschzentrum Dortmund; L. Kiesel, Universitätsklinikum Münster; M. Schellhase, D. Michel, F.F. Bier, FhG IBMT,
Potsdam
P62
Diagnostics of wood destroying basidiomycetes using DNA chip technology
N. Rangno
, Institut für Holztechnologie Dresden gGmbH; D. Müller, Biotype AG, Dresden; K. Jacobs, Institut für Holztechnologie Dresden gGmbH; C. Hiller, W. Brabetz, M. Jung,
Biotype AG, Dresden; B. Weiß, Institut für Holztechnologie Dresden gGmbH