Lecture Programme

Wednesday, 14 March 2012
10.30	Welcome
	J.-M. Piveteau President Zurich University of Applied Sciences /CH
Enabling Technologies - Stem Cells
Chair	T. May, InSCREENeX GmbH, Braunschweig/D
10.35	Keynote Lecture Stem cells derived from liver tissue
	C. Verfaillie, K.U. Leuven/B
11.20	Novel strategies for 3D neural culture and gene delivery: towards human central nervous system in vitro models for preclinical research
	C. Brito, D. Simão, P. Fernandes, M. Serra, iBET/ITQB-UNL, Oeiras/P; J. Schwarz, University of Leipzig, Leipzig/D; G. Schiavo, Cancer Research UK, London/UK; E.K. Kremer, IGMM, Montpellier/F; P.M. Alves, iBET/ITQB-UNL, Oeiras/P
11.40	Hydrogels for control of cell morphology and differentiation
	R. Mhanna, ETH, Zürich/CH; J. Becher, M. Schnabelrauch, Innovent, Jena/D; M. Zenobi-Wong, ETH, Zürich/CH
12.00	A novel strategy for cell expansion that maintains physiological properties
	C. Lipps, F. Schuller, M. Butueva, J. Zauers, H. Hauser, D. Wirth, Helmholtz Centre for Infection Research, Braunschweig/D; T. May, InSCREENeX GmbH, Braunschweig/D
12.20	Discogenic pre-conditioning of human mesenchymal stem cells in synthetic MMP-degradable poly-ethylene-glycol (PEG) hydrogels under load and rhGDF-5
	S. Guggisberg, S.C.W. Chan, University of Bern/CH; L.M. Benneker, Insel University Hospital, Bern/CH; B. Gantenbein-Ritter, University of Bern/CH
12.40	Lunch Break
Enabling Technologies - Devices for 3D Cell Culture
Chair	J. Kelm, InSphero AG, Zurich/CH
14.00	Keynote Lecture Microtechnology for microtissue handling and analysis
	A. Hierlemann, ETH Zurich/CH
14.30	A new method for engineering 3D topographical niches for cells
	S. Giselbrecht, M. Reinhardt, P. Nikolov, T. Mappes, E. Gottwald, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen/D; R. Truckenmueller, University of Twente, Enschede/NL
14.50	HepaChip^® - A microfluidic 3D liver cell culture as a tool for the in vitro assessment of liver toxicity
	J. Schütte, NMI Natural and Medical Sciences Institute, Reutlingen/D; J. Böttger, University of Leipzig/D; B. Hagmeyer, S. Werner, K. Benz, C. Freudigmann, NMI Natural and Medical Sciences Institute, Reutlingen/D; H. Becker, Microfluidic ChipShop, Jena/D; C. Höppner, BSL Bioservice, München/D; R. Gebhardt, University of Leipzig/D; M. Stelzle, NMI Natural and Medical Sciences Institute, Reutlingen/D
15.10	Fluid flow characterization of the 3D-KITChip-based bioreactor system for 3D-cell culture via magnetic resonance imaging
	E. Gottwald, T. Kleintschek, S. Giselbrecht, Karlsruhe Institute of Technology/D; R.K. Truckenmüller, University of Twente, Enschede/NL; B. Altmann, University Medical Center Freiburg/D; M. Worgull, Karlsruhe Institute of Technology/D; J. Döpfert, L. Schad, M. Heilmann, Heidelberg University/D
15.30	Materials and manufacturing technology for the fabrication of bio-inspired artifical vascular systems
	K. Borchers, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart/D; C. Bierwisch, Fraunhofer Institute for Mechanics of Materials, Freiburg/D; S. Engelhard, Fraunhofer Institute for Laser Technology, Aachen/D; C. Graf, Fraunhofer Institute for Manufacturing Engineering and Automation, Stuttgart/D; R. Jaeger, Fraunhofer Institute for Mechanics of Materials, Freiburg/D; P. Kluger, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart/D; H. Krüger, W. Meyer, Fraunhofer Institute for Applied Polymer Research, Golm/D; E. Novosel, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart/D; O. Refle, Fraunhofer Institute for Manufacturing Engineering and Automation, Stuttgart/D; C. Schuh, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart/D; N. Seiler, Fraunhofer Institute for Laser Technology, Aachen/D; G. Tovar, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart/D; M. Wegener, Fraunhofer Institute for Applied Polymer Research, Golm/D; T. Ziegler, Fraunhofer Institute for Mechanics of Materials, Freiburg/D
15.50	Coffee Break top
Enabling Technologies - Devices for 3D Cell Culture and Imaging Technologies
Chair	R. Pörtner, Hamburg University of Technology/D
16.20	Time-lapse recording of dynamic processes in 3D spheroids with light-sheet-based fluorescence microscope
	R. Richa, F. Pampaloni, E.H.K. Stelzer, Goethe University, Frankfurt am Main/D

16.40	Optimal growth of cells in 3D culture relies on the appropriate shape and form of the supporting scaffold
	S. Przyborski, Reinnervate Limited, Sedgefield/UK
17.00	Generation of bone tissue structures under dynamic conditions in a defined 3D microenvironment
	S. Kress, A. Neumann, Leibniz University Hannover/D; B. Weyand, Hanover Medical School/D; C. Kasper, University of Natural Resources and Life Sciences, Vienna/A
17.20	3D-Organotypic cultivation of liver cells
	F. Noor, D. Mueller, E. Heinzle, Saarland University, Saarbrücken/D
17.40	Keynote Lecture Light sheet-based fluorescence microscopy (LSFM) reduces phototoxic effects providing new means for modern life sciences
	Ernst Stelzer, Goethe University Frankfurt/D
18.25	Poster Session and Poster Party
- 21.00	Poster Session and Poster Party
Thursday, 15 March 2012
Advanced Cell Culture Models for Substance Testing and Understanding of Diseases
Chair	C. Burger, Merck KGaA, Darmstadt/D
09.00	Keynote Lecture Organoid cultures for target validation and drug discovery
	H. Ruffner, Novartis Pharma AG, Basel/CH
09.45	Human neurospheres as three dimensional cellular systems for developmental neurotoxicity testing
	M. Barenys, E. Fritsche, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf/D
10.05	Interactions of silica nanoparticles with an in vitro coculture model of the alveolar capillary barrier
	J. Kasper, University Medical Centre Mainz/D; M. I. Hermanns, ikfe GmbH, Mainz/D; C. Bantz, S. Utech, Johannes Gutenberg University Mainz/D; R. E. Koshkina, BAM Bundesanstalt für Materialforschung und -prüfung, Berlin/D; M. Maskos, IMM Institut für Mikrotechnik Mainz GmbH/D; E. Unger, C. J. Kirkpatrick, University Medical Centre Mainz/D
10.25	Microfluidic platform for anticancer drug screening on 3D cell culture models
	M. Håkanson, CSEM SA, Landquart/CH; J. Ruppen, O. Guenat, Berne University/CH; L. Barbe, CSEM SA, Landquart/CH
10.45	Coffee Break
Advanced Cell Culture Models for Substance Testing and Understanding of Diseases
Chair	H. Hauser, Helmholtz Centre for Infection Research, Braunschweig/D
11.15	Keynote Lecture JAK/STAT signaling in tumorigenesis
	Jaqueline Bromberg, Memorial Sloan-Kettering Cancer Center, New York/USA
12.00	The multicellular spheroid technology represents a valid test system for drug selection in early drug discovery
	A. Wagner, C. Ilmberger, S. Magosch, K. von Dehn-Rotfelser, I. Funke, B. Mayer, SpheroTec GmbH, Martinsried/D
12.20	Approching a 3D test system for arthritis and related diseases
	M. Meloni, A. Magni, B. De Servi, VitroScreen, Milan/I
12.40	Lunch Break
Advanced Cell Culture Modles for Substance Testing and Understanding of Diseases
Chair	C. Burger, Merck KGaA, Darmstadt/D
14.00	The use of reconstructed skin models for genotoxicity testing: rs micronucleus and rs comet assays
	N. Hewitt, SWS, Erzhausen/D; C. Krul, The Netherlands Organization for Applied Scientific Research, Zeist/NL; A. Reus, TNO, Zeist/NL; K. Reisinger, Henkel AG & Co KGaA, Duesseldorf/D; T. Downs, Procter & Gamble Co., Cincinnati/USA; G. Quedraogo, L'Oreal Life Sciences Research, Aulnay sous Bois/F; M. Aardema, Marilyn Aardema Consulting, MD/USA; B. Barnett, Procter & Gamble Co., Cincinnati/USA; B. Faquet, L'Oreal Life Sciences Research, Aulnay sous Bois/F; G. Mun, R. Curren, Institute for In Vitro Sciences, Inc, Gaithersburg/USA; R. Fautz, KPSS-Kao Professional Salon Services, Darmstadt/D; S. Pfuhler, Procter & Gamble Co., Cincinnati/USA
14.20	3D bioartificial corneal equivalents for predicting the eye-irritating potential of chemicals: results of an interlaboratory evaluation study
	K. Mewes, A. Fischer, K. Reisinger, Henkel AG & Co. KGaA, Düsseldorf/D; M. Zorn-Kruppa, University Hospital Hamburg-Eppendorf, Hamburg/D; D. Gabel, M. Engelke, University of Bremen, Bremen/D
14.40	Identification the pathways of drug resistance combining the Spheroid technology with Systems Biology
	B. Mayer, F. Weller, University of Munich/D; K. von Dehn-Rotfelser, SpheroTec GmbH, Munich/D; K. Halfter, University of Munich/D; S. Strobl, 4SC AG, Munich/D; Y. Heubach, NMI, Reutlingen/D; J. Eichner, University Tübingen/D; K. Jauch, University of Munich/D; I. Funke, SpheroTec GmbH, Munich/D
15.00	Keynote Lecture Roadmap to innovative toxicity testing in the 21st century in Europe and the USA
	H. Spielmann, Freie Universität Berlin/D
15.45	Coffee Break
Advanced Cell Culture Models for Substance Testing and Understanding of Diseases
Chair	H. Hauser, Helmholtz Centre for Infection Research, Braunschweig/D
16.15	Endogenous tissue contractility patterns VEGF/VEGFR2 signaling and angiogenic sprouting
	N.C. Rivron, Hubrecht Institute, Utrecht/NL; E. Vrij, J. Rouwkema, R. Truckenmuller, S. LeGac, A. van den Berg, C.A. van Blitterswijk, University of Twente, Enschede/NL
16.35	Synthetic, self-assembled nanofiber hydrogels for 3D cell culture
	M. de Jong, E. Bulten, E. Gelens, A. Tuin, Nano Fiber Matrices BV, Groningen/NL
16.55	From single tissue culture to chip based dynamic multi-organ-bioreactors
	R. Horland, G. Lindner, I. Wagner, E. Materne, S. Hoffmann, S. Brincker, A. Lorenz, M. Buseg, Technische Universität Berlin/D; F. Sonntag, Fraunhofer IWS, Dresden/D; T. Hasenberg, Technische Universität Berlin/D; N. Schilling, Fraunhofer IWS, Dresden/D; K. Schimek, M. Fischer, R. Lauster, U. Marx, Technische Universität Berlin/D
17.15	Improved three-dimensional tissue models that mimic the microenvironment of the intestine
	M. Metzger, H. Walles, University of Würzburg/D
17.35	End of Lectures
19.00	Conference Dinner at Zunfthaus zum Rüden - Registration necessary -
Friday, 16 March 2012
Advanced Cell Culture Models for ADME - Safety Testing of Drugs
Chair	U. Marx, Technical University Berlin/D
9.00	Keynote Lecture The added value of 3D hepatocyte cultures for early and mechanistic drug safety testing
	Thomas Weiser, F. Hoffmann - La Roche AG, Basel/CH
9.45	3D Cell culture model of upcyte^® hepatocytes
	C. Dähn, N. J. Hewitt, Medicyte GmbH, Heidelberg/D; D. Maltman, G. Talas, S. Przyborski, Reinnervate Ltd., Sedgefield/UK; V. Sonntag-Buck, K. Scheller, J. Braspenning, Medicyte GmbH, Heidelberg/D
10.05	An inflamed and non-inflamed triple culture model of the intestinal mucosa to assess cytotoxicity of engineered nanoparticles
	J. Susewind, Saarland University, Saarbrücken/D; C-M. Lehr, E-M. Collnot, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D
10.25	Long term maintenance of human liver cell spheroids with canalicular polarity and drug-responsive phenotype in perfusion bioreactor cultures
	R. Tostoes, S. Leite, M. Serra, ITQB/IBET, Oeiras/P; J. Jensen, B. Petter, Cellartis AB, Gothenburg/S; M.J.T. Carrondo, C. Brito, P.M. Alves, ITQB/IBET, Oeiras/P
10.45	Coffee Break
Advanced Cell Culture Models for Industrial Applications
Chair	U. Graf-Hausner, ZHAW, Zurich/CH
11.15	Establishment of a 3D co-culture proliferation assay for drug discovery
	R. de Hoogt, S. Frans, D. Wuyts, E. Gustin, F. Cornelissen, M. Cik, E. Krausz, B. Hall, P.J. Peeters, Janssen Pharmaceutical Companies of Johnson & Johnson, Beerse/B
11.35	3D Microtissues for early compound de-risking
	J. Kelm, InSphero AG, Zurich/CH
11.55	Organomimetic skin model production based on a novel bioprinting technology
	M. Rimann, M. Bleisch, ZHAW, Wädenswil/CH; M. Kuster, M. Thurner, regenHU Ltd., Villaz-St-Pierre/CH; C. Meier, A. Bossen, Bern University of Applied Sciences Engineering and Information Technology, Biel/CH; U. Graf-Hausner, ZHAW, Wädenswil/CH
12.15	Keynote Lecture Skingineering
	E. Reichmann, University Children's Hospital, Zurich/CH
12.45	Lunch
13.45	End of Conference top