Trends in Bioanalytical Imaging - Analytics and Applications
DECHEMA-Haus, Frankfurt am Main
2013-05-27 - 2013-05-28
Since the invention of the microscope in the early 17th century microscopy has opened an entirely new world to scientists. Basic biological concepts, like the cell being the building blocks of all living organisms or that microbes are the causing agents of diseases, were driven by advanced microscopic techniques.
During the last decades spectroscopic imaging has had a significant impact. Today, fluorescence and vibrational spectroscopy (IR- absorption, Raman scattering) and different types of mass spectrometry allow to gain valuable molecular information from complex biological specimens that cannot be acquired otherwise.
Bioanalytical imaging is an essential tool for the researcher who investigates the cellular and biochemical processes underlying cellular functions. Modern methods allow to analyse the spatial distribution of molecules in biological and medicinal specimens. The ultimate goal is the dynamic localization of the proteome and metabolome on the level of cells, tissues or entire organisms.
Spectroscopic methods like e.g. fluorescence or vibrational spectroscopy (IR and Raman) are of particular relevance for modern biomedical imaging since they provide, beside morphological information, direct molecular contrast. Matrix assisted laser desorption ionization coupled to mass spectrometry (MALDI-MS) is a complementary technique that opens the possibility to visualize and identify small molecules and proteins in tissues. Both imaging approaches require sophisticated bioinformatics to extract knowledge from primary data.
Bioanalytical imaging, in particular, is well suited to search for novel biomarkers needed in medicinal diagnostics or for monitoring pharmacological effects in model systems. Further aspects range from biotechnology and environmental analyses to the controling of food quality.
The first bioanalytical imaging meeting hosted by DECHEMA will cover current trends ranging from technological advances in analytics, the analysis of hidden biochemical spatial regularities, to biomarker discovery in medical, biological, and nutrition research.
In cooperation with: